Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1393266 | European Journal of Medicinal Chemistry | 2009 | 6 Pages |
Abstract
Two series of halogenated 1-benzyl-7-chloro-6-hydroxy-tetrahydroisoquinolines were prepared to explore the influence of each series on the affinity for dopamine receptors. All the compounds displayed a high affinity for D1-like and/or D2-like dopamine receptors in striatal membranes, although they were unable to inhibit [3H]-dopamine uptake in striatal synaptosomes. The halogen placed on the benzylic ring in 1-benzyl-THIQs, compounds of the series 1, 2′-bromobenzyl derivatives with Ki values into the nanomolar range, and the series 2, 2′,4′-dichlorobenzyl-THIQ homologues, proves to be an important factor to modulate affinity at dopamine receptor.
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Authors
Noureddine El Aouad, Inmaculada Berenguer, Vanessa Romero, Paloma Marín, Ángel Serrano, Sebastián Andujar, Fernando Suvire, Almudena Bermejo, M. Dolores Ivorra, Ricardo D. Enriz, Nuria Cabedo, Diego Cortes,