Synthesis and antimicrobial activities of novel quinoline derivatives carrying 1,2,4-triazole moiety

A new class of quinoline derivatives containing 1,2,4-triazole moiety were synthesized from derivatives of 4-hydroxy-8-(trifluoromethyl)quinoline-3-carbohydrazide 4 through multi-step reactions. The compound 4, on treatment with substituted Isothiocyanates yielded quinoline-thiosemicarbazides 5a–c, which were conveniently cyclized to (5-mercapto-4H-triazol-3-yl)-quinolin-4-ols 6a–c in basic medium. These intermediates were then transformed to their respective chloro derivatives 7a–c by treatment with phosphorus oxychloride, which on further reaction with different biologically active rare amines yielded the target compounds 8a–g, 9a–h and 10a–h in good yield. The ultimate step, involving nucleophilic substitution reaction was achieved by microwave-induced technique, which has reduced the reaction time drastically as well as improved the yield when compared to conventional heating. The newly synthesized final compounds were evaluated for their in vitro antibacterial and antifungal activities against four strains each. Preliminary results indicated that most of the compounds demonstrated very good antimicrobial activity, comparable to the first line standard drugs. The most effective compounds have exhibited activity at MIC of 6.25 μg/mL.

Graphical abstractNovel derivatives of 8-(trifluoromethyl) quinoline carrying 1,2,4-triazole moiety have been synthesized as potent antimicrobial agents. The most effective compounds have MIC of 6.25 μg/mL which is comparable with present antibiotics.Figure optionsDownload full-size imageDownload as PowerPoint slide