| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1393285 | European Journal of Medicinal Chemistry | 2009 | 6 Pages |
Abstract
Aminoacridine derivatives display interesting chemical and biological properties in the field of antitumor agents. The synthesis of 4-hydroxymethyl-3-aminoacridine and its iodo labelled analogue allows the study of cell distribution using two innovative, complementary and powerful techniques, real time fluorescence microscopy and dynamic secondary ion mass spectrometry (SIMS). All the data point to lysosomal localization of the active molecule.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Paul Peixoto, Walid Zeghida, Danièle Carrez, Ting-Di Wu, Nicole Wattez, Alain Croisy, Martine Demeunynck, Jean-Luc Guerquin-Kern, Amélie Lansiaux,