Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1393288 | European Journal of Medicinal Chemistry | 2009 | 5 Pages |
Abstract
In this paper we describe the design and synthesis of 18 derivatives of the antimicrobial atovaquone which were substituted at the 3-hydroxy group by ester and ether functions. The compounds were evaluated in vitro for their activity against the growth of Plasmodium falciparum, the malaria causing parasite. All the compounds showed potent activity, with IC50 values in the range of 1.25–50 nM, comparable to those of atovaquone and much higher than chloroquine or quinine.
Graphical abstractFigure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Salomé El Hage, Michèle Ane, Jean-Luc Stigliani, Maynadier Marjorie, Henri Vial, Geneviève Baziard-Mouysset, Marc Payard,