Article ID Journal Published Year Pages File Type
1393343 European Journal of Medicinal Chemistry 2009 5 Pages PDF
Abstract
A series of bis-pyridinium oximes connected by xylene linker were synthesized and their in-vitro reactivation potential was evaluated against acetylcholinesterase (AChE) inhibited by nerve agent, sarin. One of the compounds was found to be more potent than 2-PAM, a well known antidote for nerve agent poisoning.
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Physical Sciences and Engineering Chemistry Organic Chemistry
Preview
In-vitro regeneration of sarin inhibited electric eel acetylcholinesterase by bis-pyridinium oximes bearing xylene linker
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