Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1393380 | European Journal of Medicinal Chemistry | 2008 | 6 Pages |
Abstract
A series of N1-propanoyl-3,5-diphenyl-4,5-dihydro-(1H)-pyrazole derivatives were synthesized and assayed as inhibitors of MAO-A and MAO-B isoforms. Most of the tested compounds showed inhibitory activity with micromolar values and MAO-A selectivity. In addition a computational work was carried out on the most selective compound 3b to highlight the most relevant interactions in the mechanism of recognition within both the MAO-A and the MAO-B enzyme active sites.
Graphical abstractA series of N1-propanoyl-3,5-diphenyl-4,5-dihydro-(1H)-pyrazole derivatives were synthesized and assayed as inhibitors of MAO-A and MAO-B isoforms.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Franco Chimenti, Rossella Fioravanti, Adriana Bolasco, Fedele Manna, Paola Chimenti, Daniela Secci, Francesca Rossi, Paola Turini, Francesco Ortuso, Stefano Alcaro, Maria Cristina Cardia,