| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1393402 | European Journal of Medicinal Chemistry | 2008 | 8 Pages |
Abstract
This paper describes molecular docking studies of a series of classical NSAIDs with PPARγ receptor, which has been pointed as a new target for the design of anti-cancer and anti-inflammatory drugs, and has been found to be responsible for some of the already established pharmacological effects observed for marketed drugs. The results show the molecular basis of PPARγ activation by non-selective COX inhibitors.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Nelilma C. Romeiro, Carlos M.R. Sant'Anna, Lidia M. Lima, Carlos A.M. Fraga, Eliezer J. Barreiro,