| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1393431 | European Journal of Medicinal Chemistry | 2008 | 6 Pages |
The alkylation reaction of 2,2′-diseleno and 4,4′-diseleno-bis(benzoic acid) derivatives in the presence of sodium borohydride and alkyl halides allowed the synthesis of various new o- and p-alkylselenenylated benzoic acid derivatives in good yields. The anti-inflammatory activity of selected selenide derivatives on granuloma induced by subcutaneous implantation of cotton pellets in Wistar rats was examined. Selenium derivatives 2a, 2c and 2e showed anti-inflammatory activity although to a lesser extent as compared to indomethacin, however they were found less toxic than the latter.
Graphical abstractAlkylselnelyl benzoic acid derivatives were synthesized and investigated as potential anti-inflammatory agents using a granuloma induced bioassay.Figure optionsDownload full-size imageDownload as PowerPoint slide
