| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1393441 | European Journal of Medicinal Chemistry | 2008 | 6 Pages |
Abstract
A series of amide and urea derivatives of benzothiazole have been synthesized and evaluated for their antiproliferative profile in human SK-Hep-1 (liver), MDA-MB-231 (breast), and NUGC-3 (gastric) cell lines. Among them, compounds 1–2, 16–18, 23, and 25–26 had potent to moderate inhibitory activities. Further these compounds were investigated for their ability to inhibit Raf-1 activity.
Graphical abstractA series of amide and urea derivatives of benzothiazole have been synthesized and initially evaluated for their antiproliferative profile in a panel of cancer cell lines. Further potent compounds were investigated for their ability to inhibit Raf-1 activity.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Eun Young Song, Navneet Kaur, Mi-Young Park, Yinglan Jin, Kyeong Lee, Guncheol Kim, Ki Youn Lee, Jee Sun Yang, Jae Hong Shin, Ky-Youb Nam, Kyoung Tai No, Gyoonhee Han,