Synthesis and structure–antibacterial activity of triazolyl oxazolidinones containing long chain acyl moiety

A series of new piperazinyl 5-triazolylmethyl oxazolidinones containing long chain acyl group at the piperazine N-4-position were synthesized and evaluated against a panel of standard and clinical isolates of Gram-positive and Gram-negative bacteria. Derivatives having long chain acyl groups with nine or more number of carbon atoms showed significant decrease in antibacterial activity. Antibacterial activity correlated positively with heat of formation of the compounds, but correlated negatively with Clog P values, surface area, ovality and molecular volume. However, no significant correlation was observed between activity and ELUMO, EHOMO and dipole, respectively.

Graphical abstractSynthesis of new 5-triazolylmethyl oxazolidinone derivatives, their antibacterial activity and correlation with selected molecular descriptors are presented.Figure optionsDownload full-size imageDownload as PowerPoint slide