Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1393502 | European Journal of Medicinal Chemistry | 2008 | 8 Pages |
2-Substituted derivatives of diphenylpyraline and their 1-phenyl and 1-phenethyl analogues have been prepared in several steps from dihydropyridine-2(1H)-thiones. The structures of all new compounds have been confirmed by NMR spectroscopy. Their activity against Mycobacterium tuberculosis H37Rv as well as their cytotoxicity against human cells (HEK-293) have been determined via in vitro assays. The antimycobacterial potency was in general increased by substitution in ring position 2. The most promising modifications were a 2-isopropyl derivative and a 1,2-diphenyl analogue.
Graphical abstractSynthesis and antimycobacterial activity of derivatives of diphenylpyraline and their 1-phenyl analogues are reported.Figure optionsDownload full-size imageDownload as PowerPoint slide