| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1393512 | European Journal of Medicinal Chemistry | 2007 | 8 Pages |
Abstract
The synthesis of a new series of 1β-methylcarbapenems having cyclic sulfonamide moieties is described. Their in vitro antibacterial activities against both Gram-positive and Gram-negative bacteria were tested and the effect of substituent on the pyrrolidine ring was investigated. A particular compound (IIIi) having 2-methyl-[1,2,6]thiadiazinan-1,1-dioxide moiety showed the most potent antibacterial activity.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Seong Jong Kim, Hyeong Beom Park, Jae Seoung Lee, Nam Hyun Jo, Kyung Ho Yoo, Daejin Baek, Byoung-won Kang, Jung-Hyuck Cho, Chang-Hyun Oh,