Chemotherapy of leishmaniasis. Part VII: Synthesis and bioevaluation of substituted terpenyl pyrimidines

Some novel 4-N-substituted terpenyl pyrimidines 5(a–d) and 7(a–g) have been synthesized using novel synthetic methods. The compounds were screened for in vivo antileishmanial screening. When compared to 4-thiomethoxy substituted pyrimidine 2 4-N-substituted terpenyl pyrimidines 5(a–d) and 7(a–g) were found inactive.

Graphical abstractSome novel 4-N-substituted terpenyl pyrimidines 5(a–d) and 7(a–g) have been synthesized using novel synthetic methods. The compounds were screened for in vivo antileishmanial screening. When compared to 4-thiomethoxy substituted pyrimidine 2, 4-N-substituted terpenyl pyrimidines 5(a–d) and 7(a–g) were found inactive.Figure optionsDownload full-size imageDownload as PowerPoint slide