| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1393538 | European Journal of Medicinal Chemistry | 2007 | 8 Pages |
Abstract
We report the synthesis of collagen related peptides containing the peptide sequence Lys-Hyp-Gly-Glu-Hyp-Gly-Pro-Lys. The α-triple helix peptides behave as type III collagen analogues supporting platelet aggregation, while the homotrimer which does not exhibit a triple-helical conformation inhibits type III collagen-induced human platelet aggregation. The incorporation of the octapeptide sequence in type III collagen mimetic peptides may lead to the loss of the anti-thrombotic activity for a pro-thrombotic one.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Viviane Pires, Julien Pêcher, Sophie Da Nascimento, Pascal Maurice, Arnaud Bonnefoy, Alexandra Dassonville, Carole Amant, Françoise Fauvel-Lafève, Chantal Legrand, Jacques Rochette, Pascal Sonnet,