| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1393539 | European Journal of Medicinal Chemistry | 2007 | 13 Pages |
Abstract
Based on the structure of R115777 (tipifarnib, Zarnestra®), a series of farnesyltransferase inhibitors have been synthesized by modification of the 2-quinolinone motif and transposition of the 4-chlorophenyl ring to the imidazole or its replacement by 5-membered rings. This has yielded a novel series of potent farnesyltransferase inhibitors.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Patrick Angibaud, Laurence Mevellec, Christophe Meyer, Xavier Bourdrez, Patricia Lezouret, Isabelle Pilatte, Virginie Poncelet, Bruno Roux, Sophie Merillon, David W. End, Jacky Van Dun, Walter Wouters, Marc Venet,