Article ID Journal Published Year Pages File Type
1393548 European Journal of Medicinal Chemistry 2006 8 Pages PDF
Abstract

A series of new bis-quaternary ammonium compounds (bis-QACs), 4,4′-(2,9-dioxadecane) bis(1-alkylpyridinium bromide)s, 3,3′-(2,9-dioxadecane)bis(1-alkylpyridinium bromide)s and 3,3′-(2,7-dioxaoctane)bis(1-decylpyridinium bromide) was synthesized. The compounds were evaluated by their activities against bacteria, molds and yeasts; the activities were expressed as the minimum inhibitory concentrations (MIC) and/or the minimum bactericidal concentrations (MBC). Compound 4,4′-(2,9-dioxadecane) bis(1-decylpyridinium bromide) had MIC values which exceeded those of benzalkoniumchloride and thiabendazole. It was in vitro active against a broad spectrum of Gram-negative and Gram-positive bacteria, against yeasts and some molds, it had high solubility and thermal decomposition temperature. The relationships between structure and biological activity of the tested bis-QACs are discussed.

Graphical abstractA series of new bis-quaternary ammonium compounds was synthesized. Compounds had high solubility, thermal decomposition temperature and antimicrobial activities superior to those of BAC and TBZ.Figure optionsDownload full-size imageDownload as PowerPoint slide

Related Topics
Physical Sciences and Engineering Chemistry Organic Chemistry
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