Synthesis and antimicrobial activity of new (E)-4-[piperidino (4'-methylpiperidino-, morpholino-) N-alkoxy]stilbenes

The synthesis of twenty-one new (E)-4-[piperidino-(4`-methylpiperidino-, morpholino-)N-alkoxy] stilbenes is reported. The compounds were tested for antimicrobial activities against Gram-negative, Gram-positive bacteria, and fungi. In particular, compounds 3b, 3c, 3f, 3g, 3h, 3k, 3l showed good antibacterial activity against Staphylococcus aureus and 3h, 3k, 3m, 3n also against Bacillus subtilis, as well as 3h, 3n also against Streptococcus faecalis.

Graphical AbstractSynthesis and antimicrobial activity of new (E)-4-[piperidino-(4`-methylpiperidino-, morpholino-)N-alkoxy]stilbenes.Figure optionsDownload full-size imageDownload as PowerPoint slide