Article ID Journal Published Year Pages File Type
1393559 European Journal of Medicinal Chemistry 2006 8 Pages PDF
Abstract

The two series of 4,6-disubstituted 1,2,4-triazolo-1,3,4-thiadiazole derivatives 2(a–e) and 3(a–e) were synthesized and characterized using IR, 1H-NMR, CHNS analysis and by single crystal X-ray crystallographic studies. The compound 6-(2-chloro-phenyl)-3-ethyl-[1,2,4]triazole[3,4-b]thiadiazole 2b has been characterized by single crystal X-ray diffraction method. The compound crystallizes in monoclinic space group P21/c with a cell parameters a = 11.879(1) Å, b = 15.112(2) Å, c = 13.95(2) Å, Z = 8 and the final R factor is R1 = 0.0524. The structure exhibits both intra and intermolecular hydrogen bonds. The title compounds were checked for their efficacy as antimicrobials in vitro. Compounds 2b, 2c, 2d, 3b, 3c and 3d showed significant inhibition against all the strains tested, when compared to standard drugs.

Graphical abstractFigure optionsDownload full-size imageDownload as PowerPoint slide

Related Topics
Physical Sciences and Engineering Chemistry Organic Chemistry
Authors
, , , , , , ,