Increasing the binding affinity of VEGFR-2 inhibitors by extending their hydrophobic interaction with the active site: Design, synthesis and biological evaluation of 1-substituted-4-(4-methoxybenzyl)phthalazine derivatives

Extending the anilinophthalazine derivatives 4 with a substituted phenyl moiety through an uriedo linker increased the hydrophobic interaction of uriedo-anilinophthalazine derivatives 7 within the hydrophobic back pocket.