| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1394180 | European Journal of Medicinal Chemistry | 2014 | 6 Pages |
•The title compounds 10a–l were prepared from 3-hydrazonoindolin-2-ones 8a–d.•Compounds 10a–l showed a significant anticancer activity against MCF-7.•Compounds 10c, f, i exhibited the highest activity almost the same of doxorubicin.
The docking studies on CDK2 and GSK-3β inspired us to synthesis a series of indoline-2,3-dione hydrazones 10a–l. Treatment of indoline-2,3-dione derivatives 7a–d with hydrazine gave 3-hydrazonoindolin-2-ones 8a–d which were reacted with the appropriate aldehydes 9a–c to yield 3-substituted-(methylenehydrazono)indolin-2-ones 10a–l. Compounds 10a–l showed a significant anticancer activity against human breast cell line MCF-7. Compounds 10c, f, i exhibited the highest activity almost the same of doxorubicin (IC50 = 6.10 μM) with IC50 = 7.75, 6.75, 6.25 μM, respectively.
Graphical abstractIndole-2,3-dione hydrazones 10a–l showed a significant anticancer activity against human breast cell line MCF-7. Compounds 10c, f, i exhibited the highest activity almost the same of doxorubicin (IC50 = 6.10 μM) with IC50 = 7.75, 6.75, 6.25 μM, respectively.Figure optionsDownload full-size imageDownload as PowerPoint slide
