Cytotoxicity and antimicrobial activities of green synthesized silver nanoparticles

•Ag Np was synthesized using fruit extract – reducing and stabilizing agent.•Stability of Ag Np confirmed by UV–Visible and HRTEM analyses after one month.•HRTEM images showed the spherical crystalline Ag Np as small as 0.9 nm.•Ag Np showed excellent antimicrobial activities against various microorganisms.•Ag Np showed good cytotoxicity results towards MCF-7 breast cancer cell lines.

Bio-inspired silver nanoparticles are synthesized using Malus domestica (apple) extract. Polyphenols present in the apple extract act as a reducing and capping agent to produce the silver nanoparticles. UV–Visible analysis shows the surface plasmon resonance (SPR) absorption at 420 nm. The FTIR analysis was used to identify the functional groups responsible for the bio-reduction of silver ion. The XRD and HRTEM images confirm the formation of silver nanoparticles. The minimal inhibitory concentration (MIC) of silver nanoparticles was recorded against most of the bacteria and fungus. Further, MCF-7 human breast adenocarcinoma cancer cell line was employed to observe the efficacy of cancer cell killing.

Graphical abstractMIC of silver nanoparticles was recorded against most of the bacteria and fungus. Significant cytotoxic effect is exerted by biologically synthesized silver nanoparticles against MCF-7 breast cancer cells.Figure optionsDownload full-size imageDownload as PowerPoint slide