| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1394336 | European Journal of Medicinal Chemistry | 2013 | 9 Pages |
A number of linezolid-like oxazolidino-sulfonamides (7a–y and 8a–b) were designed and synthesized with a view to develop antimicrobial agents with improved properties. Most of the synthesized compounds showed good to moderate activity against a panel of standard Gram-positive and Gram-negative bacteria and fungal strains. The compounds 7i and 7v exhibited significant activity, with a MIC value of 2.0–6.0 μg/mL against a panel of Gram-positive and Gram-negative bacteria. These compounds also showed activity against Candida albicans, with a MIC value of 4.0 μg/mL. A correlation of the antimicrobial activity with calculated lipophilicity values (C log P) is also presented.
Graphical abstractA series of new oxazolidino-sulfonamides have been synthesized and evaluated for their in vitro antibacterial and antifungal activities. Further these compounds were also evaluated for their antimycobacterial activities.Figure optionsDownload full-size imageDownload as PowerPoint slideHighlights► A new series of oxazolidino-sulfonamides have been synthesized. ► These compounds were evaluated for their antimicrobial activity. ► The newly synthesized compounds exhibited significant antimicrobial activity. ► Compounds 7i and 7v exhibited significant inhibitory activity (MIC, 4.0 μg/mL). ► These compounds were also tested for their anti-tubercular activity.
