| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1394443 | European Journal of Medicinal Chemistry | 2012 | 12 Pages |
Abstract
The development of a novel class of pharmacodynamic hybrids that inhibits COX-2 isoform is reported. These molecules display enhanced nitric oxide releasing properties due to the presence of an ionisable moiety. The in vivo analgesic/anti-inflammatory activity was maintained in relation to the parent compounds.
Graphical abstractFigure optionsDownload full-size imageDownload as PowerPoint slideHighlights► Pharmacodynamic hybrids inhibiting COX-2 isoenzyme. ► Improved solubility due the introduction of an ionisable moiety on the side chain. ► An enhanced nitric oxide releasing profile was highlighted by ex-vivo studies. ► In vivo testing highlighted anti-nociceptive properties for this compounds.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Mariangela Biava, Claudio Battilocchio, Giovanna Poce, Salvatore Alfonso, Sara Consalvi, Giulio Cesare Porretta, Silvia Schenone, Vincenzo Calderone, Alma Martelli, Lara Testai, Carla Ghelardini, Lorenzo Di Cesare Mannelli, Lidia Sautebin,