Synthesis of fluorescent ristocetin aglycon derivatives with remarkable antibacterial and antiviral activities

Isoindole and benzoisoindole derivatives of ristocetin aglycon have been prepared by reaction with o-phthalaldehyde or naphthalene-2,3-dialdehyde and various thiols. The new compounds exhibited potent antibacterial and anti-influenza virus activity. The cluster forming and fluorescent properties of the aglycon derivatives were also studied.

Graphical abstractFigure optionsDownload full-size imageDownload as PowerPoint slideHighlights► Synthesis of (benzo)isoindole-substituted aglycoristocetin derivatives. ► Antibacterial data showing remarkable efficacy against resistant strains. ► High antiviral activity against influenza A viruses. ► Characterization of the fluorescent properties of new derivatives. ► Demonstration of aggregation properties.