Hybrids of privileged structures benzothiazoles and pyrrolo[2,1-c] [1,4]benzodiazepin-5-one, and diversity-oriented synthesis of benzothiazoles

Privileged structures like Benzothiazole and Pyrrolobenzodiazepine offer wonderful opportunity to explore in anti-cancer drug discovery as a mean to counter drug-resistance problem. BT-PBD hybrids and diverse BT derivatives have been synthesized and their in vitro cytotoxic activities were screened against five cancer cell lines have been discussed. The novel compounds showed promising results as compared with the marketed drug etoposide and could well be used in future anti-cancer drug development studies.

Graphical abstractFigure optionsDownload full-size imageDownload as PowerPoint slideHighlights► Novel hybrids of Benzothiazole (BT) and Pyrrolobenzodizepine (PBD) privileged structures have been synthesized. ► Diversity-oriented synthesis of Benzothiazoles. ► Interesting synthetic medicinal chemistry. ► Biological evaluation of the synthesized compounds.