| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1394528 | European Journal of Medicinal Chemistry | 2012 | 7 Pages |
Abstract
⺠An alcohol-derived acyclic 5-FU O,N-acetal has been studied for anti-cancer activity. ⺠It shows potent growth inhibition of the cell line MCF-7 at a very low concentration. ⺠ER stress-induced apoptosis is the mechanism of action against MCF-7. ⺠When it is administered to the non-neoplastic cell line MCF-10A displayed less toxicity. ⺠It has no activity against p53 and induces down-regulation of Bcl-2.
Keywords
FACScan5-FUPBSMCF-10ARMADMEMSDSUPRFITCSRBATCCMCF-7PAGEcDNAComplementary DNApolyacrylamide gel electrophoresisanalysis of variancesANOVAGene chipsodium dodecyl sulphateendoplasmic reticulumPhosphate buffered salinefluorescein isothiocyanate5-fluorouracilRobust multi-array averageAmerican Type Culture CollectionDulbecco’s modified eagle’s mediumMicroarray hybridizationpolymerase chain reactionPCRUnfolded protein responsePropidium iodide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Octavio Caba, Fernando RodrÃguez-Serrano, Mónica DÃaz-Gavilán, Ana Conejo-GarcÃa, Raúl Ortiz, Antonio MartÃnez-Amat, Pablo Álvarez, Miguel A. Gallo, JoaquÃn M. Campos, Juan A. Marchal, Antonia Aránega,