Design, synthesis and docking studies of quinoline-oxazolidinone hybrid molecules and their antitubercular properties

New series of quinoline-oxazolidinone hybrid molecules were synthesized based on the preliminary docking studies. All the newly synthesized compounds were characterized by spectral analyses. The newly synthesized compounds were screened for their antimycobacterial properties based on the promising preliminary antibacterial screening results. Amongst tested compounds, compounds 8a, 8j and 13a were active at 0.65 μg/mL against Mycobacterium tuberculosis H37Rv strain. The mode of action of these active compounds was carried out by docking of receptor enoyl-ACP reductase with newly synthesized candidate ligands 8a, 8j and 13a. These compounds exhibited well established bonds with one or more amino acids in the receptor active pocket. From the docking studies, compound 8j was considered to be the best inhibitor.

Graphical abstractNew series of quinoline-oxazolidinone hybrid molecules were synthesized and evaluated for antibacterial and anti-tubercular activities. Most of the compounds displayed promising activities.Figure optionsDownload full-size imageDownload as PowerPoint slideHighlights► Quinoline-Oxazolidinone hybrid molecules were synthesized. ► Docking studies were carried out. ► In vitro antibacterial and antimycobacterial screening were carried out. ► Compounds 8a, 8j and 13a showed promising antimycobacterial activity.