Synthesis and anti-microbial activity of some 1- substituted amino-4,6-dimethyl-2-oxo-pyridine-3-carbonitrile derivatives

A new series of 1- substituted amino-4,6-dimethyl-2-oxo-pyridine-3-carbonitrile such as hydrazide hydrazones 3a-h; ethane-1,2-diaminopyridine 6; phthalimidopyridines 8a,b; hydrazides 10a,b; urea 11a and thiourea 11b were synthesized in a good to excellent yield in step efficient process, using 1-amino-4,6-dimethyl-2-oxo-1,2-dihydropyridine-3-carbonitrile (1) as a key intermediate. The antibacterial and antifungal activities of the synthesized compounds were evaluated. The obtained data indicated that the majority of the tested compounds exhibited both antibacterial and antifungal activities, particularly compounds 8a and 8b showed a comparable effect to a well known antibacterial and antifungal agents.

Graphical abstractA series of new hydrazide hydrazones; ethane-1,2-diaminopyridine, phthalimidopyridines; hydrazides; urea and thiourea derivatives were synthesized. Their antibacterial and antifungal activities have been evaluated with phthalimide derivatives showing the highest activity.Figure optionsDownload full-size imageDownload as PowerPoint slideHighlights► Hydrazide hydrazones and ethane-1,2-diaminopyridine were synthesized. ► Antibacterial activity of compounds was evaluated against standard antibiotics. ► Antifungal activity of compounds was evaluated using standard antifungal agent. ► Phthalimide derivatives showed highest antibacterial and antifungal activities.