Article ID Journal Published Year Pages File Type
1394621 European Journal of Medicinal Chemistry 2011 10 Pages PDF
Abstract

Synthesis, molecular structure and cytotoxic activity of a series of 3-C, N, S, Se substituted benzo[b]selenophene derivatives on human fibrosarcoma HT-1080, mouse hepatoma MG-22A, and mouse fibroblasts 3T3 cell lines are described. The correlation between compound LD50 3T3 fibroblast cell line and HT-1080 morphology was shown.

Graphical abstractFigure optionsDownload full-size imageDownload as PowerPoint slideHighlights► 28 new 3-C, N, S, Se substituted benzo[b]selenophenes synthesized. ► Compounds exhibit medium cytotoxic effect in vitro. ► Cell morphology studies allowed us to compare SAR.

Related Topics
Physical Sciences and Engineering Chemistry Organic Chemistry
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