Synthesis, characterization and antimicrobial studies of some new pyrazole incorporated imidazole derivatives

In the present study two series of novel imidazole derivatives containing substituted pyrazole moiety (3a–d and 5a–j) were synthesized. The first series were synthesized by the reaction of 3-aryl-1H-pyrazole-4-carbaldehyde thiosemicarbazones (2a–d) with DMAD and the second series by the reaction of 3-aryl-1H-pyrazole-4-carbaldehydes (1a–e) with 1,2-diketones (4a,b) in the presence of ammonium acetate. Structures of newly synthesized compounds were characterized by spectral studies. New compounds were screened for antifungal and antibacterial activities. Among the synthesized compounds, compound 3c was found to be potent antimicrobial agent. The acute oral toxicity study for the compound 3c was carried out and the experimental studies revealed that compound 3c is safe up to 3000 mg/kg and no death of animals were recorded.

Graphical abstractTwo series of novel substituted imidazole derivatives containing substituted pyrazole moiety were synthesized, characterized and their antimicrobial studies were performed. Figure optionsDownload full-size imageDownload as PowerPoint slideHighlights► Two new series of imidazoles were synthesized. ► Compounds were characterized by spectral studies. ► Antimicrobial evaluation of newly synthesized molecules was carried out. ► Toxicity study of 3c was also performed.