Conventional and microwave assisted synthesis of Some new N-[(4-oxo-2-substituted aryl −1, 3-thiazolidine)-acetamidyl]-5-nitroindazoles and its antimicrobial activity

Several new N-[(4-oxo-2-substituted aryl-1, 3-thiazolidine)-acetamidyl]-5-nitroindazoles (4a–l) were synthesized from N-(arylidene amino acetamidyl)-5-nitroindazoles (3a–l). The reactions were carried out by both conventional as well as microwave method. The structures of these compounds were confirmed by IR, 1H NMR, 13C NMR, FAB-mass spectra and also by microanalytical data. The newly synthesized compounds were evaluated for their antimicrobial activity against variety of bacterial and fungal strains. The compounds 4g and 4h showed the maximum antibacterial activity (MIC 11 and 10 μg/mL) against Escherichia coli and antifungal activity (MIC 9 and 8 μg/mL) against Fusarium oxysporum.

Graphical abstractSeveral new N-[(4-oxo-2-substituted aryl-1,3-thiazolidine)-acetamidyl]-5-nitroindazole (4a–l) were synthesized from N-(arylidene amino acetamidyl) – 5-nitroindazoles (3a–l). The reactions were carried out by both conventional as well as microwave method. some of these compounds have shown significant antibacterial and antifungal activities Figure optionsDownload full-size imageDownload as PowerPoint slide