Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1394742 | European Journal of Medicinal Chemistry | 2010 | 6 Pages |
In our effort to discover and develop small molecule multi-pathway inhibitors which may be useful as tools for treating cancerous conditions, we have synthesized a small library of 2-thiazole-5-yl-3H-quinazolin-4-one derivatives. Synthesized compounds were evaluated as inhibitors of NF-κB and AP-1 mediated transcriptional and eIF-4E mediated translational activation as these transcription and translation factors are known to play a pivotal role in initiation and progression of cancer. The results from the study suggest the utility of the 2-thiazole-5-yl-3H-quinazolin-4-one scaffold as a promising scaffold for the design of novel multi-pathway inhibitors, which can be explored as anti-cancer agents.
Graphical abstractThis study describes the synthesis and evaluation of 2-thiazole-5-yl-3H-quinazolin-4-one derivatives as inhibitors of multiple pathways involved in cancerous conditions.Figure optionsDownload full-size imageDownload as PowerPoint slide