Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1394750 | European Journal of Medicinal Chemistry | 2010 | 10 Pages |
Abstract
A series of triarylolefins bearing the combretastatin A-4 and the isocombretastatin A-4 cores were synthesized and evaluated. The cooperative ortho-effect of a labile bromine atom in the regioselective hydrostannation of unsymmetrical diarylalkynes leading to stereodefined triarylolefins is presented.
Graphical abstractA novel series of CA-4-isoCA-4 hybrids have been synthesized. All of the compounds were evaluated for their cytotoxic and antimitotic properties.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Evelia Rasolofonjatovo, Olivier Provot, Abdallah Hamze, Jérome Bignon, Sylviane Thoret, Jean-Daniel Brion, Mouâd Alami,