| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1394782 | European Journal of Medicinal Chemistry | 2010 | 9 Pages |
Abstract
A series of graveoline and graveolinine derivatives were synthesized. The biological results showed that most of graveoline derivatives possessed higher cytotoxicity and better inhibitive effect against the adhesion and migration of human umbilical vein endothelial cell (HUVEC) than graveolinine derivatives. Among these compounds, 8d was the most potent agents that also showed significant anti-angiogenesis activities in chick embryo chorioallantoic membrane (CAM) assay.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Zeng-Yun An, Yi-Yong Yan, Dan Peng, Tian-Miao Ou, Jia-Heng Tan, Shi-Liang Huang, Lin-Kun An, Lian-Quan Gu, Zhi-Shu Huang,