Synthesis of N-methyl-bisindolylmaleimide amino acid methyl ester conjugates and cytotoxicity study

A novel series of N-methylbisindolylmaleimides derivatives bearing 2-acetamino acid moieties were synthesized. The cytotoxic activities of these compounds were tested in six tumor cell lines. The most potent compound 8d displayed cytotoxicity against six human tumor cell lines in the micromolar range.

Graphical abstractA novel series of N-methylbisindolylmaleimides derivatives bearing 2-acetamino acid moieties were synthesized. The most potent compound 8d displayed cytotoxicity against six human tumor cell lines in the micromolar range.Figure optionsDownload full-size imageDownload as PowerPoint slide