Synthesis, structure and in vitro antibacterial activities of new hybrid disinfectants quaternary ammonium compounds: Pyridinium and quinolinium stilbene benzenesulfonates

The series of pyridinium (1–10) and quinolinium (11–20) stilbene benzenesulfonates have been synthesized and their structures were investigated by UV–vis, FT-IR and 1H NMR spectroscopy. In addition, compound 5 was also determined by single crystal X-ray diffraction technique. The antibacterial activity of the synthesized compounds against both Gram-positive and Gram-negative bacteria has been determined. The quinolinium derivatives exhibited two very potent characteristic activities, namely, (i) specific activity to Methicillin-Resistant Staphylococcus aureus and (ii) with broad band spectrum activity. Compounds 11, 13 and 14 are the most active showing broad spectrum antibacterial activity against Gram-positive (Methicillin-Resistant S. aureus, S. aureus, Bacillus subtilis, Vancomycin-Resistant Enterococcus faecalis and E. faecalis) and Gram-negative bacterium (Shigella sonnei). The MICs of these compounds were found to be better than that of Benzalkonium chloride (BZK), the commercially used disinfectant.

Graphical abstractThe new pyridinium and quinolinium stilbene benzenesulfonates have been synthesized and characterized. All compounds were evaluated for their antibacterial activity against the tested Gram-positive and Gram-negative bacteria using colorimetric assay.Figure optionsDownload full-size imageDownload as PowerPoint slide