Synthesis and biological evaluation of N-aryl-1,4-dihydropyridines as novel antidyslipidemic and antioxidant agents

N-aryl-1,4-dihydropyridines 2a–n were synthesized via iodine catalyzed three-component reaction of cinnamaldehydes, anilines and 2-keto esters in methanol. The synthesized compounds were screened for their antidyslipidemic and antioxidant activity in vivo and in vitro. Compounds 2a, 2g, and 2l have exhibited promising lipid and TG lowering activity, whereas compounds 2m and 2n have showed potent antioxidant activity.

Graphical abstractWe have synthesized N-aryl-1,4-dihydropyridines via iodine catalyzed three-component coupling reaction of cinnamaldehydes, anilines and 2-keto esters. The synthesized compounds have exhibited promising antidyslipidemic and antioxidant activities. Figure optionsDownload full-size imageDownload as PowerPoint slide