| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1394985 | European Journal of Medicinal Chemistry | 2010 | 8 Pages |
Two new ligands maip (1a), paip (1b) with their ruthenium (II) complexes [Ru(bpy)2(maip)](ClO4)2 (2a) and [Ru(bpy)2(paip)](ClO4)2 (2b) have been synthesized and characterized. The results show that complexes 2a and 2b interact with DNA through intercalative mode. The cytotoxicity of these compounds has been evaluated by MTT assay. The experiments on antioxidant activity show that these compounds exhibit good antioxidant activity against hydroxyl radical (OH).
Graphical abstractTwo new ruthenium (II) complexes [Ru(bpy)2(maip)]2+ (2a) and [Ru(bpy)2(paip)]2+ (2b) have been synthesized and characterized. Their DNA-binding, cytotoxcity and antioxidant activity against hydroxyl radical have been studied.Figure optionsDownload full-size imageDownload as PowerPoint slide
