Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1394988 | European Journal of Medicinal Chemistry | 2010 | 10 Pages |
Abstract
A new family of phenstatin analogues has been synthesized and assayed. This family simultaneously incorporates modifications of the A-ring (replacement of the 3,4,5-trimethoxyphenyl by the 2,3,4-trimethoxyphenyl arrangement), B-ring (N-alkyl-5-indolyl) and conversion of the Oxygen keto group into a substituted nitrogen (oximes, hydrazones, and their acetylderivatives). The conjunction of all this changes greatly diminishes the antimitotic and antiproliferative activities, but the maintenance of the keto bridge produces a potent analogue with the unusual 2,3,4-trimethoxyphenyl moiety.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Concepción Álvarez, Raquel Álvarez, Purificación Corchete, Concepción Pérez-Melero, Rafael Peláez, Manuel Medarde,