Synthesis of nitroimidazole derived oxazolidinones as antibacterial agents

A series of N-alkylated derivatives of nitroimidazolyl oxazolidinones 6a–i with various substituent at N-1 position of the nitroimidazole were synthesized and their in-vitro antibacterial activities were evaluated against several Gram-positive and Gram-negative bacteria. The 6a was found to be most potent compound in the series with MIC at 0.097 μg/mL against Bacillus cereus MTCC 430.). Both 6a and 6f did not exhibit any toxicity towards mammalian cell L929.

Graphical abstractA series of nitroimidazole derived oxazolidinones 6a–i with various substituents at the nitroimidazole were synthesized and their in-vitro antibacterial activities were evaluated against several Gram-positive and Gram-negative resistant bacteria. The 6a was found to be most potent compound in the series with MIC at 0.097 μg/mL against Bacillus cereus (MTCC 430). Both 6a and 6f did not exhibit any toxicity towards mammalian cell L929.Figure optionsDownload full-size imageDownload as PowerPoint slide