Synthesis, characterization and biological activities of some new benzo[b]thiophene derivatives

Benzo[b]thiophene molecules are found to be important tools in synthetic medicinal chemistry. They are of current interest due to their wide spectrum of pharmacological properties. In view of the biological activities of benzo[b]thiophene containing molecules, in this present research work, we propose the synthesis of some new benzo[b]thiophene derivatives such as thiadiazoles, oxadiazoles, pyrazolin & diaryl pyrazoles starting from 3-chlorobenzo[b]thiophene-2-carboxyl chloride. These newly synthesized compounds were characterized by elemental analyses, I.R, NMR and Mass spectral studies. Some of the selected compounds were screened for their antibacterial, antifungal and anti-inflammatory studies. Many of the molecules were found to be potent.

Graphical abstractSeries of new benzo[b]thiophene derivatives were synthesized, characterized and their antimicrobial and anti-inflammatory studies were performed. Few of the compounds showed significant antimicrobial and anti-inflammatory activity.Figure optionsDownload full-size imageDownload as PowerPoint slide