Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1395060 | European Journal of Medicinal Chemistry | 2009 | 5 Pages |
Abstract
In this work, we synthesized and evaluated the cytotoxic effect of [Ru(phi)3]2+, on rat C6 glioma cell line. Cell viability was determined by assay with 3-(4-5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT). The mutagenicity of [Ru(phi)3]2+ was studied in vitro by using two strains of Salmonella typhimurium with frameshift mutation (TA98) and base-pair substitution mutation (TA100) were used in plate incorporation assay in the absence of metabolic activation. According to the results, the Ru compound is not toxic but mutagenic, and it shows cytotoxic effect towards C6 rat glioma cells in100 μM.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Kadriye Benkli, Yağmur Tunali, Zerrin Cantürk, Öge Artagan, Filiz Alanyali,