A novel and efficient one step synthesis of 2-amino-5-cyano-6-hydroxy-4-aryl pyrimidines and their anti-bacterial activity

The first simple and efficient approach towards one step synthesis of 2-amino-5-cyano-6-hydroxy-4-aryl pyrimidines has been developed by three component condensation of aromatic aldehydes, ethyl cyanoacetate and guanidine hydrochloride in alkaline ethanol. The synthesized compounds evaluated for their anti-bacterial activity against Gram-positive and Gram-negative bacteria. The some of the compounds showed excellent zone of inhibition against tested bacteria.

Graphical abstractThe first simple and efficient approach towards one step synthesis of 2-amino-6-hydroxy-4-(phenyl)-pyrimidine-5-carbonitrile has been reported by three component condensation of aromatic aldehydes, ethyl cyanoacetate and guanidine hydrochloride using alkaline ethanol. The synthesized compounds evaluated for their anti-bacterial activity against Gram-positive and Gram-negative bacteria.Figure optionsDownload full-size imageDownload as PowerPoint slide