A diaryl sulfide, sulfoxide, and sulfone bearing structural similarities to combretastatin A-4

Studies examining various spacer groups that link the two aromatic rings of combretastatin A-4 (CA4) have shown that the biological activity of analogs does not require the cis-stilbene configuration of CA4. Oxygen or nitrogen, carbonyl, methylene and ethylene spacers, for example, are present in CA4 analogs that show good activity. Up to now sulfur was not tested for this purpose. In this article we describe the synthesis of sulfide, sulfoxide and sulfone spacers between two aromatic rings comparable to those of CA4. We also compared them with CA4 for inhibitory effects on cell growth, tubulin polymerization, and the binding of [3H]colchicine to tubulin. We found that the sulfide is highly active and may be a lead compound for the preparation of antitumor compounds.

Graphical abstractHerein it is described the synthesis of sulfur-containing spacers between two aromatic rings comparable to those of CA4. We compared them with CA4 for antitubulin activity. We found that the sulfide is highly active.Figure optionsDownload full-size imageDownload as PowerPoint slide