Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1395163 | European Journal of Medicinal Chemistry | 2009 | 6 Pages |
Abstract
The human A3 adenosine receptor agonistic activity of 2-chloro-N6-substituted-4â²-thioadenosine-5â²-uronamides has been quantitatively analyzed in terms of topological 0D-, 1D- and 2D-descriptors based on molecular graph theory using Combinatorial Protocol in Multiple Linear Regression (CP-MLR). The models developed and the participating descriptors suggest that the substituent groups hold scope for further modification in the optimization of activity.
Keywords
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Susheela Sharma, Brij K. Sharma, Sanjeev K. Sharma, Prithvi Singh, Yenamandra S. Prabhakar,