Article ID Journal Published Year Pages File Type
1395163 European Journal of Medicinal Chemistry 2009 6 Pages PDF
Abstract
The human A3 adenosine receptor agonistic activity of 2-chloro-N6-substituted-4′-thioadenosine-5′-uronamides has been quantitatively analyzed in terms of topological 0D-, 1D- and 2D-descriptors based on molecular graph theory using Combinatorial Protocol in Multiple Linear Regression (CP-MLR). The models developed and the participating descriptors suggest that the substituent groups hold scope for further modification in the optimization of activity.
Related Topics
Physical Sciences and Engineering Chemistry Organic Chemistry
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