Recent developments of 2-aminothiazoles in medicinal chemistry

•2-Aminothiazole is an important and versatile scaffold in drug design and discovery.•2-Aminothiazole -based compounds have been shown diverse biological activities.•Many 2-aminothiazoles are known as anticancer, antimicrobial, anticonvulsant and antidiebatic agents.•Newly identified 2-aminothiazoles in recent years and their application in medicinal chemistry are summarized in the review.

The 2-aminothiazole (2-AT) core is an active pharmacophore and used in medicinal chemistry and drug discovery research. A number of drugs with 2-AT core are in the market, e.g. Famotidine, Cefdinir, Meloxcam etc. Recently, 2-AT core has been explored for many more important therapeutic areas and identified new 2-aminothiazoles with anticancer, antitumor, antidiebatic and anticonvulsant activity. In this review, we discuss the newly identified and developed 2-aminothiazoles in recent years and their use in medicinal chemistry and pharmacology.

Graphical abstractFigure optionsDownload full-size imageDownload as PowerPoint slide