| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1395300 | European Journal of Medicinal Chemistry | 2009 | 7 Pages |
Abstract
A series of substituted spiro[3′]pyrazolinylphosphonates and spiro[3]diazaphospholes were synthesized via 1:3-dipolar cycloaddition reaction of 2-diazonio-1,3-dioxo-2,3-dihydro-1H-inden-2-ide with phosphonyl carbanions: diethyl-cyanomethylphosphonate, -phosphono-acetates, and -vinylphosphonate. On the other hand, treatment of the diazo substrate with diethyl (thiomethyl)methylphosphonate led to the formation of condensed oxadiazine and spiro[3]diazaphosphole. Some compounds were found to possess antibacterial and antifungal activities.
Graphical abstractReaction of 2-diazo-1,2,3-triketone with phosphonyl carbanions yielded substituted phospholes and phophonates.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Wafaa M. Abdou, Maha D. Khidre, Rizk E. Khidre,