Hansch analysis of veratric acid derivatives as antimicrobial agents

The synthesis, characterization and antimicrobial evaluation of a new series of veratric acid derivatives are presented. Preliminary in vitro antimicrobial activity of the title compounds was assessed against a panel of microorganisms including Gram-positive and Gram-negative bacteria and fungi. Some of the veratric acid derivatives exhibited significant in vitro antimicrobial activity. QSAR investigation applied to find a correlation between different physicochemical parameters of the veratric acid derivatives and their antimicrobial activity indicated the importance of topological parameters in describing the antimicrobial activity.

Graphical abstractThe Hansch analysis of veratric acid derivatives as antimicrobial agents demonstrated the importance of topological parameters in describing their antimicrobial activity.Figure optionsDownload full-size imageDownload as PowerPoint slide