Article ID Journal Published Year Pages File Type
1395459 European Journal of Medicinal Chemistry 2007 7 Pages PDF
Abstract
A novel synthetic approach to N-aryl-4-(3-pyridyl)thiazol-2-amine and analogues using HMCM-41 and their in vitro ADP-induced platelet aggregation inhibitory activity on human blood platelets is described. Among the test compound, N-(2′-flourophenyl)-4-(3-pyridyl)thiazol-2-amine (9e) was found to be the most potent, IC50 = 4.84 × 10−7 M.
Related Topics
Physical Sciences and Engineering Chemistry Organic Chemistry
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