Synthesis of indazole motifs and their medicinal importance: An overview

•Indazoles are heterocyclic compound, abundantly found in naturally occurring alkaloids.•Various methods for the synthesis of 1H and 2H indazoles derivatives have been discussed.•These biologically active compounds showed several activities such as, protein kinase inhibitors, active against cancer cell proliferative disorders, Azheimer's disease, auto immune and neuro degenerative disorders.

Indazoles is an important class of heterocyclic compounds having a wide range of biological and pharmaceutical applications. There is enormous potential in the synthesis of novel heterocyclic systems to be used as building blocks for the next generation of pharmaceuticals as anti-bacterial, anti-depressant and anti-inflammatory. Fused aromatic 1H and 2H-indazoles are well recognized for anti-hypertensive and anti-cancer properties. The present review focuses on novel routes of their synthesis and various biological activities.

Graphical abstractIndazoles, a class of heterocyclic compounds attracted an attention of chemist due to their wide range of several pharmaceutical applications. It is used in pharmaceuticals for anti-bacterial, anti-depressant, anti-inflammatory activities etc. Fused 1H and 2H-indazoles are well recognized for anti-hypertensive and anti-cancer properties.Figure optionsDownload full-size imageDownload as PowerPoint slide